摘要: |
目的:探讨血清总胆汁酸对于肝细胞肝癌(简称肝癌)患者的预后意义。方法:收集145例肝癌患者的临床资料并随访其生存期,比较总胆汁酸升高组和正常组两组患者之间临床因素的差异,通过单因素、多因素分析影响肝癌患者总生存期的预后因素。结果:高胆汁酸组患者在多个肝功能指标上与正常胆汁酸水平组患者存在显著差异,血清总胆红素>17.1 μmol/L(22.6% vs 7.2%)、白蛋白<35 g/L(32.3% vs 7.2%)、GGT>70 U/L(59.7% vs 39.8%)、PT>14 s(27% vs 7.2%)的患者比例明显高于正常胆汁酸水平患者(P<0.05)。多因素分析结果显示:总胆汁酸>10 μmol/L(HR=1.595,P=0.029)、有门静脉侵犯(HR=2.102,P=0.005)、有远处转移(HR=1.922,P=0.035)是影响肝癌患者总生存期的独立危险因素。结论:总胆汁酸是影响肝癌患者预后的独立危险因素。 |
关键词: 肝细胞肝癌 总胆汁酸 预后 |
DOI:10.12025/j.issn.1008-6358.2019.20190519 |
分类号:R 575 |
基金项目:国家自然科学基金青年基金(81602034). |
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The prognostic value of total bile acid for patients with hepatocellular carcinoma |
王 妍,周颖婷,陈荣新,任正刚,张 岚
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Abstract: |
Objective:To explore the prognostic value of total bile acid (TBA) for patients with hepatocellular carcinoma. Methods:The clinical data of 145 patients with hepatocellular carcinoma were collected and their overall survival time was followed up. The differences of clinical factors between TBA high group and TBA normal group were compared. The prognostic factors affecting the overall survival of patients with hepatocellular carcinoma were analyzed by univariate and multivariate analysis. Results:There were significant differences in liver function between TBA high group and normal group. The proportion of patients with serum total bilirubin>17.1 μmol/L (22.6% vs 7.2%), albumin<35 g/L (32.3% vs 7.2%), GGT>70 U/L (59.7% vs 39.8%), and PT>14 s (27% vs 7.2%) were significantly higher in TBA high group than those in TBA normal group (P<0.05). The multivariate analysis results showed that TBA>10 μmol/L (HR=1.595, P=0.029), portal vein invasion (HR=2.102, P=0.005), and distant metastasis (HR=1.922, P=0.035) were independent risk factors for overall survival of patients with HCC. Conclusions:TBA is an independent prognostic factor for patients with hepatocellular carcinoma. |
Key words: hepatocellular carcinoma total bile acid prognosis |