摘要: |
具核梭杆菌(fusobacterium nucleatum,Fn)与结直肠癌(colorectal cancer,CRC)发生有关。有研究发现人类CRC中有过量的Fn,并阐明了Fn在体外和小鼠模型中参与CRC发生可能的机制。Fn参与CRC癌变的机制主要包括:通过增加髓系来源的抑制细胞和减少自然杀伤细胞等发挥的免疫调节;由FadA、Fap2和脂多糖介导的毒力作用;促进肿瘤相关microRNA(如miR-21)表达;代谢作用。本文就Fn在CRC中的作用机制作一综述。 |
关键词: 结直肠癌 具核梭杆菌 机制 |
DOI:10.12025/j.issn.1008-6358.2020.20190397 |
分类号:R735.3 |
基金项目: |
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Research progress on mechanisms of fusobacterium nucleatum promoting colorectal cancer |
LV Zhen-tao, ZHONG Yun-shi, CHEN Tao, ZHOU Ping-hong
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Department of Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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Abstract: |
Fusobacterium nucleatum (Fn) has been linked to colorectal cancer (CRC). Several studies showed an overabundance of Fn in human CRC and elucidated the possible mechanisms of Fn involved in CRC in vitro and in mouse models. The mechanisms of Fn involved in CRC carcinogenesis mainly include immune modulation by increasing myeloid-derived suppressor cells and decreasing natural killer cells, toxic effect mediated by FadA, Fap2, and lipopolysaccharide, increasing tumor-associated microRNAs (such as miR-21), and metabolism modulation. This article reviews the mechanisms of Fn in CRC. |
Key words: colorectal cancer fusobacterium nucleatum mechanisms |