摘要: |
随着研究的不断深入,非编码RNA(non-coding RNA,ncRNA)的功能越来越多地被发现。ncRNA可通过调控表观遗传、转录及转录后翻译等在正常生理过程中发挥作用,与肿瘤和心血管病等疾病的发生发展关系密切。近年来文献报道,ncRNA(microRNA与lncRNA)与腹主动脉瘤的发展密切相关。其通过调控内皮细胞功能紊乱、平滑肌细胞凋亡、细胞外基质降解以及炎症等过程参与腹主动脉瘤的发生发展过程。本文旨在总结ncRNA在腹主动脉瘤发生发展中作用的研究进展。 |
关键词: 非编码RNA 腹主动脉瘤 调控机制 |
DOI:10.12025/j.issn.1008-6358.2019.20190143 |
分类号:R 654.3 |
基金项目: |
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Progress in the study of non-coding RNA in abdominal aortic aneurysm |
方超,丁勇,符伟国,蒋俊豪
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Abstract: |
With the deepening of research, more and more functions of non-coding RNA (ncRNA) have been revealed. The ncRNA can play an important role in normal physiological processes by regulating epigenetics, transcription, and post-transcriptional translation. ncRNA is also closely related to the development of diseases such as tumors and cardiovascular diseases. In recent years, some researches have revealed that ncRNA (microRNA and lncRNA) is closely related to the development of abdominal aortic aneurysm. ncRNA may participate in the development of abdominal aortic aneurysm by regulating endothelial cell dysfunction, smooth muscle cell apoptosis, extracellular matrix degradation, and inflammation. This article aims to summarize the research progress of ncRNA in the development of abdominal aortic aneurysm. |
Key words: non-coding RNA abdominal aortic aneurysm regulation mechanism |