摘要: |
目的:探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者中血清磷(serum phosphorus)与振动感觉阈值(vibrating perception threshold,VPT)之间的相关性。方法:入选T2DM患者1 027例,根据VPT进行分层,振动觉正常组(n=535例)、振动觉减退组(n=294例)及振动觉缺失组(n=198例),比较各组血清磷及相关指标的差异,采用Spearman相关分析和Stepwise多元逐步回归分析评价血清磷与VPT相关性。结果:与振动觉正常组相比,振动觉减退组和振动觉缺失组患者年龄更大、病程更长(P<0.05)。与振动觉减退组相比,振动觉缺失组患者病程更长(P<0.05)。与振动觉正常组相比,振动觉减退组和振动觉缺失组患者eGFR和血清磷水平降低(P<0.05)。与振动觉减退组相比,振动觉缺失组患者eGFR和血清磷水平降低(P<0.05)。Spearman相关分析显示,年龄(r=0.454, P<0.001)和病程(r=0.289, P<0.001)与VPT显著正相关;eGFR(r=-0.251, P<0.001)和血清磷(r=-0.145, P<0.001)与VPT显著负相关。多元逐步回归分析显示年龄、病程、HbA1c、eGFR及血清磷是VPT的独立危险因素。结论:2型糖尿病患者血清磷与VPT显著负相关,是VPT的独立危险因素。 |
关键词: 2型糖尿病 血清磷 振动感觉阈值 糖尿病周围神经病变 |
DOI:10.12025/j.issn.1008-6358.2019.20190071 |
分类号:R 587.1 |
基金项目:复旦大学附属上海市第五人民医院助推项目(No.2018WYZT03),上海市闵行区自然科学基金(No.2017MHZ06),上海市卫生和计划生育委员会卫生行业临床研究专项(No.201840119). |
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Correlation between serum phosphorus and vibration perception threshold in patients with type 2 diabetes mellitus |
丁和远,石 蕾,盛 励, 王艳华,查兵兵,刘 军
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Abstract: |
Objective:To explore the correlation between serum phosphorus (P) and vibration perception threshold (VPT) in patients with type 2 diabetes mellitus (T2DM). Methods:A total of 1 027 patients with T2DM were enrolled in this study. They were stratified according to VPT: vibration sensation normal group (n=535), vibrational hypoesthesia group (n=294), and vibration sensation deficiency group (n=198). The correlation between serum P and VPT was evaluated by Spearman correlation analysis and Stepwise multiple stepwise regression analysis. Results:Compared with the vibration sensation normal group, the age and duration of the vibrational hypoesthesia group and vibration sensation deficiency group were older and longer (P<0.05). Compared with the normal group, eGFR and P of the vibrational hypoesthesia group and vibration sensation deficiency group decreased significantly (P<0.05). Compared with the vibrational hypoesthesia group, eGFR and P of vibration sensation deficiency group decreased significantly (P<0.05). Spearman correlation analysis showed that age (r=0.454, P<0.001) and duration (r=0.289, P<0.001) were positively correlated with VPT, while eGFR (r=-0.251, P<0.001) and P (r=-0.145, P<0.001) were negatively correlated with VPT. Multiple stepwise regression analysis showed that age, duration, HBA1c, eGFR, and P were independent risk factors for VPT. Conclusions:Serum P is positively correlated with VPT and is an independent risk factor for VPT in patients with type 2 diabetes mellitus. |
Key words: type 2 diabetes mellitus serum phosphorus vibration perception threshold diabetic peripheral neuropathy |