摘要: |
目的:探讨2型糖尿病合并代谢综合征(MS)患者血清趋化素水平的变化及其与白细胞介素6(IL-6)的相关性。
方法:选择108例初诊2型糖尿病患者,其中合并MS组(MS组)58例、不合并MS组(非MS组)50例。另选取同期40例健康体检者作为对照组。测定3组患者血清趋化素、IL 6水平及空腹血糖(FBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、血脂,并计算稳态模型胰岛素抵抗指数(HOMA-IR)、体质指数(BMI)、腰臀比(WHR)。
结果:MS组血清趋化素水平为(77.2±9.2) ng/mL,显著高于非MS组[(65.3±6.5) ng/mL,P<0.05] 及对照组[(56.5±6.2) ng/mL,P<0.01];MS组血清IL-6水平为(48.8±6.4) pg/mL,显著高于非MS组[(41.4±7.2) pg/mL,P<0.01]及对照组[(32.7±4.9) pg/mL,P<0.01]。Pearson相关分析显示,2型糖尿病合并MS患者血清趋化素水平与收缩压、BMI、腰围、WHR、HOMA-IR、三酰甘油(TG)、IL-6均正相关(P<0.05),与高密度脂蛋白胆固醇(HDL-C)负相关(P<0.01)。
结论:2型糖尿病合并MS患者血清趋化素水平升高,与IL-6水平正相关。 |
关键词: 2型糖尿病 代谢综合征 趋化素 白细胞介素6 |
DOI:10.12025/j.issn.1008-6358.2018.20180370 |
分类号:R 587.1 |
基金项目:国家自然科学青年基金(81500655),浦东新区公利医院博士后科研基金(GLBH2017005),上海市浦东新区卫生系统重点学科建设项目(PWZxk2017-07). |
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Relationship between serum chemerin and interleukin-6 in patients with type 2 diabetes combined with metabolic syndrome |
MA Jun-hua, LU Jian-can, WANG Xing, ZHU Hong-ling, GU Ming-jun*
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Department of Endocrinology, Gongli Hospital, Navy Military Medical University, Shanghai 200135, China
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Abstract: |
Objective:To detect the levels of serum chemerin in type 2 diabetic patients combined with metabolic syndrome (MS) and investigate the relationship between chemerin and interleukin-6 (IL-6).
Methods:The clinical data of 108 newly diagnosed type 2 diabetic patients were analyzed, among which, 58 patients were assigned to the MS group and 50 patients were assigned to the non MS group. Forty healthy patients during the same period were selected as the control group. The levels of serum chemerin, IL-6, fasting blood-glucose (FBG), glycosylated hemoglobin A1c (HbAlc), fasting insulin (FINS), and serum lipid were detected in three groups. Homeostasis model assessment of insulin resistance (HOMA-IR), body mass index (BMI) and waist-to-hip ratio (WHR) were calculated.
Results:Serum chemerin level was significantly higher in MS group than that in non MS group and control group ([77.2±9.2] ng/mL vs[65.3±6.5] ng/mL, [77.2±9.2] ng/mL vs[56.5±6.2] ng/mL, P<0.05 and P<0.01, respectively). Compared with non-MS group and control group, the serum IL-6 level was significantly increased in MS group[48.8±6.4] pg/mL vs[41.4±7.2] pg/mL,[48.8±6.4] pg/mL vs[32.7±4.9]pg/mL, P<0.01, respectively). Pearson correlation analysis showed that serum chemerin level was positively correlated with diastolic blood pressure, BMI, waist circumference, WHR, HOMA-IR, triglyceride (TG), and IL-6 (all P<0.05), and was negatively correlated with high-density lipoprotein cholesterol (HDL-C, P<0.01).
Conclusions:Serum chemerin level is increased in type 2 diabetic patients with MS, and the level of serum chemerin is positively correlated with IL-6. |
Key words: type 2 diabetes mellitus metabolic syndrome chemerin interleukin-6 |