摘要: |
目的:探讨黏膜相关淋巴组织(MALT)国际预后指数(IPI)在中国人群MALT淋巴瘤患者中的适用性,并比较不同风险分层方法对MALT淋巴瘤的预后评估价值。方法:回顾2007年1月至2016年12月129例MALT淋巴瘤患者的临床资料,采用Kaplan-Meier法和log-rank法计算并比较MALT-IPI与IPI不同分层分组患者的总体生存率(OS)和无进展生存率(PFS)。结果:129例患者中位发病年龄56岁(22~82岁),其中胃MALT淋巴瘤53例(41.1%),肺MALT淋巴瘤33例(25.6%);Ann Arbor Ⅰ~Ⅱ期71例(55.1%),Ⅲ~Ⅳ期58例(44.9%)。中位随访时间26个月(1~378个月)。总体5年PFS为 69.41%,5年OS为90.23%。IPI评分低危、中低危和中高危/高危组患者5年OS、PFS差异无统计学意义;MALT-IPI评分低危、中危和高危组患者5年OS、PFS率逐渐降低,差异有统计学意义(P<0.05)。结论:MALT-IPI评分适用于中国人群;相较于IPI评分,MALT IPI评分对MALT淋巴瘤患者预后具有更好的评估价值。 |
关键词: 淋巴瘤 黏膜相关淋巴组织 预后 |
DOI:10.12025/j.issn.1008-6358.2018.20180185 |
分类号:R 733.4 |
基金项目:国家自然科学基金(81570123),上海市卫生系统优秀学科带头人项目(2017BR033),上海市卫生和计划生育委员会科研课题(201440390). |
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Prognostic value of mucosa-associated lymphoid tissue International Prognostic Index in Chinese patients with mucosa-associated lymphoid tissue lymphoma |
LI Jing, WEI Zheng, LIANG Li-fan, ZHANG Xue-jiao, ZHANG Yi-an, LIU Peng*
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Department of Hematology,Zhongshan Hospital,Fudan University,Shanghai 200032,China
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Abstract: |
Objective:To explore the applicability of mucosa associated lymphoid tissue (MALT) International Prognostic Index (MALT-IPI) in Chinese patients with MALT lymphoma and compare the prognostic value of different risk stratification methods for MALT lymphoma. Methods:A total of 129 patients with MALT lymphoma diagnosed and treated in Zhongshan Hospital, Fudan University between January 2007 and December 2016 were analyzed retrospectively. Survival analysis was performed according to the MALT IPI and IPI scoring system. Results:The median age of patients was 56 years old (range, 22-82 years old). Fifty-three patients (41.1%) had gastric MALT lymphoma. Lung involvement was found in 25.6% cases. More than half of patients presented with limited stage disease (71 patients stage Ⅰ-Ⅱ, 55.1%) at diagnosis, and the remaining 58 (44.9%) patients were in stage Ⅲ-Ⅳ. The median follow-up period was 26 months (range, 1-378 months). The 5-year overall survival (OS) rate and 5-year progression-free survival (PFS) rate were 90.23% and 69.41%, respectively. For IPI scoring system, the 5-year PFS rate in low-, low-intermediate-, high-intermediate/high-risk groups were 74.8%, 65.2%, and 58.2%, respectively (P=0.125); while for the MALT-IPI model, the 5-year PFS rate in low-, intermediate-, high-risk groups for MALT-IPI were 82.4%, 58.4%, and 47.2%, respectively (P=0.003). Conclusions:MALT-IPI is suitable for Chinese MALT lymphoma patients. In comparison with IPI, MALT-IPI would be a more proper prognostic index for the prediction of OS and PFS in patients with MALT lymphoma. |
Key words: lymphoma mucosa-associated lymphoid tissue prognosis |