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李青, 易婷, 青玉凤. 慢性痛风石发生机制研究进展[J]. 中国临床医学, 2018, 25(6): 1016-1019.
引用本文: 李青, 易婷, 青玉凤. 慢性痛风石发生机制研究进展[J]. 中国临床医学, 2018, 25(6): 1016-1019.
Research progress on pathogenesis of chronic gouty tophus[J]. Chin J Clin Med, 2018, 25(6): 1016-1019.
Citation: Research progress on pathogenesis of chronic gouty tophus[J]. Chin J Clin Med, 2018, 25(6): 1016-1019.

慢性痛风石发生机制研究进展

Research progress on pathogenesis of chronic gouty tophus

  • 摘要: 痛风石可导致关节活动受限、关节畸形。尿酸盐溶解度、离子浓度、结缔组织中因子和蛋白、中性粒细胞胞外网状陷阱等因素与尿酸钠(MSU)结晶的形成、增大密切相关。其中,尿酸盐浓度升高是唯一确定的MSU结晶形成的关键因素。

     

    Abstract: Gouty tophus contributed to joint activity limitation and deformation in patients. The urate solubility, concentration of ions, connective tissue proteins, and neutrophil extracellular traps factors all have relationship with the nucleation and growth of monosodium urate(MSU) crystal, among which, the increase of urate concentration is the only identified factor for the MSU crystallization.

     

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