摘要: |
近年来,急性呼吸窘迫综合征(acute respiratory distress syndrome, ARDS)的遗传学机制被广泛研究。基因变异通过调节基因功能而影响ARDS的易感性和临床预后,被视为潜在的生物标志及靶标。然而基因变异与ARDS的发病机制的内在关联仍不明确。本文将主要探讨与基因变异(涉及炎症反应、微血管功能改变及凝血机制)与ARDS发病易感性和预后的相关性,为未来的研究提供参考。 |
关键词: 基因变异 急性呼吸窘迫综合征 靶向治疗 |
DOI:10.12025/j.issn.1008-6358.2018.20171183 |
分类号:R 563.8 |
基金项目:国家自然科学基金(81471840,81171837,31471190,31671317),上海市中医药三年行动计划(ZY3-CCCX3-3018,ZHYY-ZXYJH-201615),上海市卫计委重要薄弱学科建设项目(2016ZB0202),上海市卫计委青年研究基金(20134Y023),复旦大学附属中山医院骨干基金. |
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Research progress on association between genetic variants and the susceptibility and outcomes of acute respiratory distress syndrome |
CHEN Yao,SONG Zhen-ju*
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Department of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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Abstract: |
The genetic mechanism of the acute respiratory distress syndrome (ARDS) has been widely studied. Genetic variations influence the susceptibility and outcomes of ARDS via affecting the function of genes and are considered as the potential biomarkers and therapeutic targets. Nevertheless, the innate relationship between genetic variations and the pathogenesis of ARDS remains obscure. This review summarizes the latest studies on this topic concerning the influence of genetic variations on the inflammatory response, microvascular function, and coagulation mechanism, in hopes of bringing some illumination for the future studies. |
Key words: genetic variation acute respiratory distress syndrome targeted therapy |