摘要: |
凝血酶敏感蛋白1(thrombospondin-1, TSP-1)是一种分泌性细胞外基质糖蛋白,具有多个功能区域,可以结合不同的蛋白或受体,如转化生长因子β(transforming growth factor-β, TGF-β)、CD36、CD47及整合素等,介导血管新生、细胞黏附、血小板聚集及免疫反应等。机体多种细胞可以合成TSP-1,如血小板、血管内皮细胞、平滑肌细胞、脂肪细胞、成纤维细胞、肝星状细胞、角质细胞等。近年来,随着TSP-1在肿瘤、代谢的调控作用的研究深入,其在脂质代谢、胰岛素抵抗、非酒精性脂肪肝等糖脂代谢中发挥的作用正逐渐被人们认识。 |
关键词: 凝血酶敏感蛋白1 胰岛素抵抗 脂质代谢 非酒精性脂肪肝 CD36 |
DOI:10.12025/j.issn.1008-6358.2018.20170988 |
分类号:R 589.2 |
基金项目:国家自然科学基金(8157040318). |
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Research progress on thrombospondin 1 in the regulation of glucose and lipid metabolism |
BAI Jin-yun, GAO Xin*
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Abstract: |
Thrombospondin-1(TSP-1) is a secreted extracellular matrix glycoprotein, with multiple functional domains which can bind to different protein or receptors including transforming growth factor-β, CD36, CD47, and integrins. TSP-1 plays a role in cellular adhesion, angiogenesis, cell migration, and platelet accumulation. TSP-1 can be synthesized by various cells, such as platelets, vascular endothelial cells, smooth muscle cells, adipocytes, fibroblasts, hepatic stellate cells, keratinocytes, etc.Recently, some studies have revealed that TSP-1 isinvolved in cancer and metabolism regulation. What’s more, TSP-1 also has effects on lipid metabolism, insulin resistance, and non-alcoholic fatty liver disease(NAFLD). |
Key words: thrombospondin-1 insulin resistance lipid metabolism non-alcoholic fatty liver disease CD36 |