摘要: |
目的:观察巴塞罗那临床肝癌分期及治疗策略(Barcelona Clinic Liver Cancer Staging,BCLC) B期肝癌患者经动脉化疗栓塞术(transarterial chemoembolization,TACE)前后血管内皮生长因子(VEGF)表达水平的变化规律,探讨其可能的临床意义。方法:17例BCLC B期肝癌患者行TACE治疗。收集患者TACE术前1 d及术后1、3、5、7、14、30 d时外周静脉血,检测血VEGF表达水平,分析VEGF表达变化与肝癌生物学特性的关系。结果:与TACE术前1 d相比,术后1 d血VEGF有所升高,术后3、5 d有所下降,术后14 d较前均明显升高,差异有统计学意义(P<0.05)。存在肝动脉 门静脉瘘、随访CT/MRI发现明显新发病灶患者血VEGF水平较高。17例患者中疗效较好10例,疗效较差7例;两组间VEGF变化在术后14 d差异有统计学意义(P<0.05)。结论:血浆VEGF表达水平可作为BCLC B期患者TACE治疗潜在的疗效评估指标。 |
关键词: 血管内皮生长因子 肝细胞肝癌 经动脉化疗栓塞术 临床肝癌分期 |
DOI:10.12025/j.issn.1008-6358.2017.20170025 |
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Abstract: |
Objective:To investigate the changes of plasma VEGF levels and its relationship with efficacy of transarterial chemoembolization (TACE) for patients with Barcelona Clinic Liver Cancer Staging (BCLC) stage B hepatocellular carcinoma, and also discuss its possible clinical significance. Methods:Peripheral blood samples were collected at 1 d before TACE and at 1, 3, 5, 7, 14, 30 d after TACE from 17 patients with BCLC stage B HCC. The relationship between plasma VEGF level and biological or imaging characteristics pre and post TACE were analyzed. Results:Compared with 1 day before surgery, the VEGF level at 1 day after surgery was improved, and decreased at 3 and 5 days after surgery, but increased significantly at 14 days after surgery (P<0.05). Higher levels of plasma VEGF were observed in patients with fistula between hepatic artery and portal vein, or with tumor recurrence. Good response to TACE were observed in 10 patients, 7 patients with poor response. There were significant differences between two groups on plasma VEGF level at 14 d post TACE(P<0.05). Conclusions:The plasma VEGF level can be regarded as index to evaluate the efficacy of TACE for patients with BCLC B stage. |
Key words: vascular endothelial growth factor hepatocellular carcinoma transcatheter arterial chemoembolization clinic liver cancer staging |