摘要: |
目的:探讨新西兰大白兔组织工程骨股骨旁异位成骨(ectopic bone formation)的效果。方法:选取新西兰大白兔骨髓基质干细胞进行成骨诱导,与生物陶瓷构建组织工程骨,种植到新西兰大白兔股骨的骨膜旁,第8周获得异位成骨组织,检测分析收获的异位成骨材料结构。结果:第8周的异位成骨材料内有骨组织形成,成骨材料结构清晰,组织内部有新血管形成,荧光蛋白标记的标本有荧光蛋白表达。结论:组织工程骨在体内可顺利异位成骨;结构可以顺利异位成骨。 |
关键词: 组织工程骨 异位成骨 结构 |
DOI:10.12025/j.issn.1008-6358.2017.20160775 |
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Abstract: |
Objective:To study the structure of ectopic bone formed beside the New Zealand rabbit femoral bone. Methods:Bone marrow stroma stem cells (BMSCs) were taken from New Zealand rabbits to built engineered bone constructs, the constructs were embedded near the rabbit femoral bone, the ectopic bone constructs were harvested at 8th week for further examination and study. Results:At 8th week, the ectopic bone had a clear bone like structure, together with new blood supply, green fluorescent protein could be seen in samples seeded by marked cells. Conclusions:This study showed that the ectopic bone formation could be successful in vivo. |
Key words: engineered bone constructs ectopic bone formation structure |