摘要: |
目的:探讨2型糖尿病患者脑白质病变(white matter lesions,WMLs)与轻度认知功能障碍(mild cognitive impairment,MCI)的关系及WMLs相关危险因素分析。方法:选择124例2型糖尿病患者,根据头颅MRI结果分为WMLs组及无WMLs组。124例均接受认知功能测评。采集一般临床资料(身高、体质量、糖尿病病程、高血压病史),检测空腹血糖、糖化血红蛋白、血脂、肝肾功能等生化指标并留取晨尿。分析WMLs与认知功能是否存在相关性及WMLs相关危险因素。结果:WMLs组MCI的发生率高于无WMLs组(P=0.027)。两组年龄、收缩压、舒张压、体质指数、空腹血糖、肌酐、尿酸、肾小球滤过率及高血压病史差异有统计学意义(P<0.05)。Logistic回归分析提示,年龄、肌酐、尿酸、肾小球滤过率是2型糖尿病患者WMLs的独立危险因素。结论:2型糖尿病患者WMLs与MCI相关,年龄增加、肾功能损害加重与WMLs独立相关。 |
关键词: 2型糖尿病 脑白质病变 轻度认知功能障碍 |
DOI:10.12025/j.issn.1008-6358.2017.20160560 |
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Abstract: |
Objective:To investigate the relationship between cerebral white matter lesions (WMLs) and mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus and analyze the related risk factors. Methods:Totally 124 cases of patients with type 2 diabetes were divided into WMLs group and non WMLs group according to the results of brain magnetic resonance imaging and accepted the cognitive function assessment. General clinical data (height, weight, duration of diabetes, hypertension history) were collected. Biochemical index such as fasting glucose, glycosylated hemoglobin, blood lipids, and renal function were tested and the first morning urine was collected. Correlation analysis of cerebral white matter lesions and MCI was performed and related risk factors were clarified. Results:The proportion of MCI in group with WMLs was higher than that of non WMLs group (P=0.027) . The statistical significances of age, systolic pressure, diastolic blood pressure, body mass index, fasting blood glucose, high density lipoprotein cholesterol (HDL C), creatinine, uric acid, glomerular filtration rate and hypertension history were found between two groups (P<0.05). Logistic regression analysis showed that age, creatinine, uric acid, glomerular filtration rate were the independent risk factors of WMLs in patients with type 2 diabetes. Conclusions:WMLs is associated with MCI in patients with type 2 diabetes. The increase of age, the deterioration of the renal damage are independently related with WMLs. |
Key words: type 2 diabetes white matter lesions mild cognitive impairment |