Abstract: Diabetic cardiomyopathy (DCM) is an independent ischemic heart disease that occurs on the basis of diabetes, excluding diseases originated from the heart itself. The pathogenesis of DCM is caused by multiple factors and is still not well elucidated. It involves the injury of cardiac myocytes, hyperglycemia, energy metabolism disorder, and cardiac microvascular disease. Adiponectin (APN) has been found to be able to reduce the level of glycemia and regulate blood lipids, and has anti-apoptotic, anti-inflammatory, and antioxidant properties, as also be able to prevent atherosclerosis, and has close relationship with the development of DCM. Therefore, this article describes and summarizes the role of adiponectin in DCM.