Abstract: Objective：To explore the efficacy of magnetic auricular acupressure combined with antiemetic drugs on postoperative nausea and vomiting (PONV) in patients undergoing thyroidectomy. Methods：Totally 46 patients undergoing thyroidectomy were randomly assigned into multi mode group (M group, n=23) receiving magnetic auricular acupressure combined with granisetron and dexamethasone, and single mode group (S group, n=23) receiving only granisetron and dexamethasone. The incidences of PONV at 0-2 h, 2-6 h, 6-24 h, and 0-24 h after operation and visual analogue scale (VAS) scores at 2, 6, 24 h after operation were compared between two groups. Results：A total of 23 cases in M group and 20 cases in S group completed the study. The general characteristics, surgery time and anesthesia time were not significantly different between two groups. No significant differences were found in history of PONV, motion sickness, and smoking between two groups. There was no significant difference in dosage of sufentanil between groups. The incidences of nausea at 0-2 h, 2-6 h, 6-24 h and 0-24 h after operation in M group were significantly lower than those in S group (all P<0.05), and the incidences of vomiting at 0-2 h and 0-24 h after operation in M group were also significantly lower than those in S group (both P<0.05). The patient satisfaction of PONV management in M group was enhanced compared with that in S group (P=0.004). There was no significant difference between groups in using antiemetic drug. The VAS scores at 2 h and 6 h after operation were significantly lower in M group than those in S group (both P<0.05), while there was no significantly different at 24 h after operation. The extubation time, response time to instruction, and recovery quality score at 24 h after operation were not statistically different between two groups. Conclusions：Compared with single drug mode, multi modes strategy such as magnetic auricular acupressure combined with antiemetic drugs can significantly reduce the incidence of PONV and relieve the early postoperative pain in patients undergoing thyroidectomy.