Abstract: Objective：To study the influencing factors of serum high-sensitivity cardiac troponin T (hs-cTnT) levels in chronic kidney disease (CKD) patients. Methods：The clinical data of CKD patients treated at a hospital were collected. Fasting blood samples were collected to measure the level of hs-cTnT. Single factor analysis, univariate linear regression analysis and multiple linear regression analysis were carried out to screen the influencing factors of hs-cTnT. Results：The level of hs-cTnT was detected in 324 CKD patients, and the median level was 0.012 μg/L. In early-stage CKD patients, Cys C, UACR and left ventricular mass index (LVMI) were positively correlated with hs-cTnT level (P<0.05), and the hs-cTnT level increased significantly in CKD patients with hypertension or diabetes. The estimated glomerular filtration rate (eGFR) was negatively correlated with the hs-cTnT level (P=0.003). Conclusions：The elevated levels of hs-cTnT in CKD patients are associated with a variety of factors, so clinicians should make a comprehensive assessment of the causes of elevated hs-cTnT level.