Abstract: Objective：To investigate the psychological depression of obese patients with acanthosis nigricans (AN), in order to provide evidence for clinical treatment. Methods：From March 2014 to August 2014, a total of 88 consecutive patients with obese were treated in our department, 56 agematched normal weight healthy volunteers were included as control group. They were divided into simple obesity group (OB, n=30) and obesity with acanthosis nigricans group (AN, n=58). The selfadministrated Beck Depression InventoryⅡ questionnaire was used in three groups, and general characteristics and clinical data were collected for analysis. Results：Compared with OB group, AN group had higher levels of FFA and UA (P<0.05). The severity of depression was significantly higher in AN group than OB group and the control group (P<0.05). The frequency of depression was recorded as 67.2% in the AN group, 43.4% in OB group, and 3.6% in control group (P<0.05). Conclusions：Obese patients with AN has severer metabolism disorder and severity of depression than simple obesity patients. Psychotherapy is necessary for AN patients when treat for obesity.