Abstract: The diagnosis and treatment of motor system diseases are faced with some difficulties, such as unclear mechanism, low diagnostic efficiency, difficult model construction, slow drug development, and hard to bionic repair. Bone/cartilage organoids are a kind of tissue that can simulate the structure and function of bone/cartilage tissue by three-dimensional cultured cells in vitro. It provides a disruptive tool for research on bone/cartilage diseases and greatly revolutionize clinical diagnosis and treatment strategies in orthopedics. This paper systematically introduces the strategies and current research status of constructing bone/cartilage organoids to address the diagnostic and therapeutic dilemmas of bone/cartilage diseases. It proposes cutting-edge advancements that revolutionize clinical diagnosis and treatment strategies while summarizing the three stages of development from basic organoids, structured organoids to functionalized organoids.