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李祖浩, 陈晓, 苏佳灿. 骨/软骨类器官技术变革骨/软骨疾病临床诊疗策略[J]. 中国临床医学, 2024, 31(3): 335-342. DOI: 10.12025/j.issn.1008-6358.2024.20240493
引用本文: 李祖浩, 陈晓, 苏佳灿. 骨/软骨类器官技术变革骨/软骨疾病临床诊疗策略[J]. 中国临床医学, 2024, 31(3): 335-342. DOI: 10.12025/j.issn.1008-6358.2024.20240493
LI Zuhao, CHEN Xiao, SU Jiacan. Bone/cartilage organoid technology transforming clinical diagnosis and treatment strategies[J]. Chinese Journal of Clinical Medicine, 2024, 31(3): 335-342. DOI: 10.12025/j.issn.1008-6358.2024.20240493
Citation: LI Zuhao, CHEN Xiao, SU Jiacan. Bone/cartilage organoid technology transforming clinical diagnosis and treatment strategies[J]. Chinese Journal of Clinical Medicine, 2024, 31(3): 335-342. DOI: 10.12025/j.issn.1008-6358.2024.20240493

骨/软骨类器官技术变革骨/软骨疾病临床诊疗策略

Bone/cartilage organoid technology transforming clinical diagnosis and treatment strategies

  • 摘要: 运动系统疾病诊疗面临机制研究不清、诊断效率低下、模型构建困难、药物研发缓慢、难以仿生修复等难题。骨/软骨类器官是一种新技术,通过体外三维培养细胞构建可模拟骨/软骨结构和功能的组织,为骨/软骨疾病研究提供新工具,变革了骨科临床诊疗策略。本文针对骨/软骨疾病诊疗困境,系统介绍了骨/软骨类器官构建策略及研究现状,提出变革临床诊疗策略的前沿进展,总结骨/软骨类器官从基础类器官、结构化类器官到功能化类器官的3个发展阶段,以期为骨/软骨类器官基础与临床转化研究提供参考。

     

    Abstract: The diagnosis and treatment of motor system diseases are faced with some difficulties, such as unclear mechanism, low diagnostic efficiency, difficult model construction, slow drug development, and hard to bionic repair. Bone/cartilage organoids are a kind of tissue that can simulate the structure and function of bone/cartilage tissue by three-dimensional cultured cells in vitro. It provides a disruptive tool for research on bone/cartilage diseases and greatly revolutionize clinical diagnosis and treatment strategies in orthopedics. This paper systematically introduces the strategies and current research status of constructing bone/cartilage organoids to address the diagnostic and therapeutic dilemmas of bone/cartilage diseases. It proposes cutting-edge advancements that revolutionize clinical diagnosis and treatment strategies while summarizing the three stages of development from basic organoids, structured organoids to functionalized organoids.

     

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