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胡永, 陈一兴, 杜世锁, 等. 肿瘤坏死因子α在肝细胞癌中的研究进展[J]. 中国临床医学, 2024, 31(2): 257-261. DOI: 10.12025/j.issn.1008-6358.2024.20231745
引用本文: 胡永, 陈一兴, 杜世锁, 等. 肿瘤坏死因子α在肝细胞癌中的研究进展[J]. 中国临床医学, 2024, 31(2): 257-261. DOI: 10.12025/j.issn.1008-6358.2024.20231745
HU Yong, CHEN Yixing, DU Shisuo, et al. Research progress of tumor necrosis factor-α in hepatocellular carcinoma[J]. Chinese Journal of Clinical Medicine, 2024, 31(2): 257-261. DOI: 10.12025/j.issn.1008-6358.2024.20231745
Citation: HU Yong, CHEN Yixing, DU Shisuo, et al. Research progress of tumor necrosis factor-α in hepatocellular carcinoma[J]. Chinese Journal of Clinical Medicine, 2024, 31(2): 257-261. DOI: 10.12025/j.issn.1008-6358.2024.20231745

肿瘤坏死因子α在肝细胞癌中的研究进展

Research progress of tumor necrosis factor-α in hepatocellular carcinoma

  • 摘要: 肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)是一种多功能炎性细胞因子,在肿瘤发生和发展中具有双向调节作用,对肝细胞癌(hepatocellular carcinoma,HCC)的发生、发展调节途径多样,机制尚不完全清楚。血管内皮生长因子(vascular endothelial growth factor,VEGF)分子信号通路和核因子κB(nuclear factor kappa B,NF-κB)信号通路在HCC发生和发展中扮演着重要的角色。外周血TNF-α浓度和肿瘤组织中TNF-α浓度对HCC患者接受一些治疗后的预后表现出了较好的预测价值,但对接受精确放疗的HCC患者预后预测价值,需要被进一步明确。

     

    Abstract: Tumor necrosis factor-α (TNF-α) is a multifunctional inflammatory cytokine that has a bidirectional regulatory role in the occurrence and development of tumors. TNF-α participates in various regulatory pathways for the occurrence and development of hepatocellular carcinoma (HCC), but the mechanisms are not fully clear. Vascular endothelial growth factor (VEGF) and nuclear factor kappa B (NF-κB) signal pathways are considered as important roles in the occurrence and development of HCC. Peripheral blood TNF-α concentration and tumor tissue TNF-α concentration have shown good predictive values for the prognosis of HCC patients after receiving some treatments. The prognostic predictive value of TNF-α for HCC patients receiving precise radiotherapy needs to be further clarified.

     

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