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王玉豪, 盛文旭, 倪筝, 等. 肾源性腺瘤临床病理特征分析[J]. 中国临床医学, 2024, 31(3): 470-476. DOI: 10.12025/j.issn.1008-6358.2024.20230673
引用本文: 王玉豪, 盛文旭, 倪筝, 等. 肾源性腺瘤临床病理特征分析[J]. 中国临床医学, 2024, 31(3): 470-476. DOI: 10.12025/j.issn.1008-6358.2024.20230673
WANG Yuhao, SHENG Wenxu, NI Zheng, et al. Analysis of the clinicopathological characteristics of nephrogenic adenoma[J]. Chinese Journal of Clinical Medicine, 2024, 31(3): 470-476. DOI: 10.12025/j.issn.1008-6358.2024.20230673
Citation: WANG Yuhao, SHENG Wenxu, NI Zheng, et al. Analysis of the clinicopathological characteristics of nephrogenic adenoma[J]. Chinese Journal of Clinical Medicine, 2024, 31(3): 470-476. DOI: 10.12025/j.issn.1008-6358.2024.20230673

肾源性腺瘤临床病理特征分析

Analysis of the clinicopathological characteristics of nephrogenic adenoma

  • 摘要:
    目的 探讨肾源性腺瘤(nephrogenic adenoma,NA)临床病理及免疫组织化学(immunohistochemistry, IHC)特征。
    方法 收集2016年7月至2022年10月经复旦大学附属中山医院病理科确诊的13例NA患者临床资料,分析其临床病理特征。
    结果 13例NA患者中,男性11例,女性2例。受累部位:输尿管(n=7)、膀胱(n=5)、膀胱及输尿管(n=1)、肾盂(n=2)。NA患者有输尿管狭窄(6/7)、膀胱壁粗糙(3/5)及肾盂息肉(2/2)表现。NA镜下表现为管状(13/13)及乳头状(4/13)结构,被覆立方/柱状上皮(13/13)或混合鞋钉样嗜酸上皮(12/13);间质疏松,内含不等量血管及炎细胞(13/13)。IHC示CK7、PAX-8、CK19、CK8特异表达。
    结论 NA为泌尿系统罕见肿瘤,组织学特征独特,有过度诊疗和漏诊风险,也有复发和恶变潜能。NA确诊需病理诊断,IHC检测有助于病理诊断。

     

    Abstract:
    Objective To explore the clinicopathological and immunohistochemical features of nephrogenic adenoma (NA).
    Methods Clinical data of NA patients diagnosed in the Department of Pathology, Zhongshan Hospital, Fudan University from July 2016 to October 2022 were collected and analyzed to explore their clinicopathological features.
    Results A total of 13 NA cases were enrolled. There were 11 males and 2 females. Organs involved: ureter (n=7), bladder (n=5), bladder and ureter (n=1), renal pelvis (n=2). NA patients performed as ureteral stenosis (6/7), rough bladder wall (3/5), and renal pelvis polyp (2/2). The typical microscopical features of NA were tubular (13/13) and papillary (4/13) structures, covered with cuboidal or columnar epithelium (13/13), or a mixed hobnail-spike eosinophilic epithelium (12/13); the interstitium was loose, containing varied amounts of vasculature and inflammatory cells (13/13). Immunohistochemistry revealed specific expressions of CK7, PAX-8, CK19 and CK8.
    Conclusions NA is a rare neoplasm of the urinary system with unique histological features. NA has the risk of misdiagnosis and over-treatment, and the potential of recurrence and malignant conversion. The diagnosis of NA depends on pathology, and the immunohistochemistry can be helpful for its pathological diagnosis.

     

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