Abstract:
Objective To explore the clinicopathological and immunohistochemical features of nephrogenic adenoma (NA).
Methods Clinical data of NA patients diagnosed in the Department of Pathology, Zhongshan Hospital, Fudan University from July 2016 to October 2022 were collected and analyzed to explore their clinicopathological features.
Results A total of 13 NA cases were enrolled. There were 11 males and 2 females. Organs involved: ureter (n＝7), bladder (n＝5), bladder and ureter (n＝1), renal pelvis (n＝2). NA patients performed as ureteral stenosis (6/7), rough bladder wall (3/5), and renal pelvis polyp (2/2). The typical microscopical features of NA were tubular (13/13) and papillary (4/13) structures, covered with cuboidal or columnar epithelium (13/13), or a mixed hobnail-spike eosinophilic epithelium (12/13); the interstitium was loose, containing varied amounts of vasculature and inflammatory cells (13/13). Immunohistochemistry revealed specific expressions of CK7, PAX-8, CK19 and CK8.
Conclusions NA is a rare neoplasm of the urinary system with unique histological features. NA has the risk of misdiagnosis and over-treatment, and the potential of recurrence and malignant conversion. The diagnosis of NA depends on pathology, and the immunohistochemistry can be helpful for its pathological diagnosis.
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