| Evaluation of long-term protective efficacy of neonatal immunoprophylaxis in children whose mothers have hepatitis B virus |
| Received:June 20, 2021 Revised:August 24, 2021 Click here to download the full text |
| Citation of this paper:XU Chen-yu,CHEN Ting-mei,HUANG Hong-yu,WANG Qin,HU Ya-li,ZHOU Yi-hua.Evaluation of long-term protective efficacy of neonatal immunoprophylaxis in children whose mothers have hepatitis B virus[J].Chinese Journal of Clinical Medicine,2021,28(5):833-837 |
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| Author Name | Affiliation | E-mail | | XU Chen-yu | Department of Obstetrics and Gynecology, Zhenjiang Maternal and Child Health Hospital, Zhenjiang 212001, Jiangsu, China | | | CHEN Ting-mei | Department of Obstetrics and Gynecology, Zhenjiang Maternal and Child Health Hospital, Zhenjiang 212001, Jiangsu, China | | | HUANG Hong-yu | Laboratory of Hepatitis, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210008, Jiangsu, China | | | WANG Qin | Department of Obstetrics and Gynecology, Zhenjiang Maternal and Child Health Hospital, Zhenjiang 212001, Jiangsu, China | | | HU Ya-li | Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210008, Jiangsu, China | | | ZHOU Yi-hua | Laboratory of Hepatitis, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210008, Jiangsu, China | zgr03summer@126.com |
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| Abstract:Objective: To explore the long-term protective efficacy of neonatal immunoprophylaxis in children whose mothers have hepatitis B virus (HBV). Methods: A cohort of 246 children whose mothers have hepatitis B and hepatitis B surface antigen (HBsAg) negative from November 2011 and March 2012. They were scheduled to have a second follow-up from January to May 2017. The data of hepatitis B revaccination and hepatitis history during two follow-ups were recorded, and blood samples were collected for the hepatitis B markers examination. Results: A total of 197 (80.1%) children, with a mean age of (8.9±1.4) years, participated in the follow-up. All children were HBsAg negative, and 99 (50.3%) children were anti-HBs positive (≥ 10 mU/mL). during the two follow-ups, 31 children were revaccinated with the hepatitis B vaccine. Among these children, the median anti-HBs level increased from 10.7 to 98.4 mU/mL (P<0.05), and the anti-HBs positive rate increased from 51.6% to 93.5% (P<0.05). Among 166 children who did not receive revaccination, the median anti-HBs level dropped from 41.7 to 7.3 mU/mL (P<0.05), anti-HBs became negative in 67 children, and the positive rate of anti-HBs decreased from 77.7% to 42.2% (P<0.05). Of 37 children, with anti-HBs <10 mU/mL at the first follow-up, 28 (75.7%) still had anti-HBs <10 mU/mL. In addition, 30 (18.1%) of the 166 un-revaccinated children showed increased anti-HBs levels, but no one was anti-HBc positive. Conclusions: After neonatal immunoprophylaxis, anti-HBs level in children of HBsAg-positive mothers was declined with the growing age and most unrevaccinated children had anti-HBs <10 mU/mL, but none of them was infected with HBV. These results indicate that neonatal immunoprophylaxis has long-term protection against HBV and revaccination is not required. |
| keywords:hepatitis B virus mother offspring immunoprophylaxis antibody to hepatitis B surface antigen long-term protection |
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