| Association between preoperative infection status of hepatitis B virus and prognosis of primary liver cancer |
| Received:April 17, 2021 Revised:July 01, 2021 Click here to download the full text |
| Citation of this paper:SANG Rui-rui,YANG Chun-chen,SHEN Zao-zhuo,HE Yi-feng,HUANG Xiao-wu,SHI Jie-yi,ZHOU Rong.Association between preoperative infection status of hepatitis B virus and prognosis of primary liver cancer[J].Chinese Journal of Clinical Medicine,2021,28(5):838-841 |
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| Author Name | Affiliation | E-mail | | SANG Rui-rui | Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | YANG Chun-chen | Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | SHEN Zao-zhuo | Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | HE Yi-feng | Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | HUANG Xiao-wu | Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | SHI Jie-yi | Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, China | shi.jieyi@zs-hospital.sh.cn | | ZHOU Rong | Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai 200032, China | zhou.rong1@zs-hospital.sh.cn |
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| Abstract:Objective: Hepatitis B virus (HBV) infection is a risk factor for primary liver cancer. This article aims to explore the relationship between the preoperative HBV infection status and the prognosis after liver cancer resection. Methods: Totally, 910 patients with hepatocellular carcinoma undergoing radical resection were randomly selected. Clinicopathological information, preoperative hepatitis B marker serological examination, and follow-up data were used to analyze the relationship between preoperative hepatitis B infection status and patient prognosis. Results: 95.1% of patients undergoing surgery for liver cancer had hepatitis B virus infection, of whom the "small three positives" were the most common, accounting for 57.0%. The postoperative tumor-free survival rate and overall survival rate of HBV-DNA-positive patients were significantly lower than those of negative patients (P<0.05). HBV-DNA was positively correlated with liver cirrhosis, alpha-fetoprotein level, tumor size, and vascular invasion (P<0.001). Conclusions: Enhancing the detection of hepatitis B serum markers is beneficial for the prevention and treatment of liver cancer and could improve patient prognosis. |
| keywords:hepatitis B immunological examinations of hepatitis B HBV-DNA primary liver cancer |
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