| Application value of apparent diffusion coefficient in predicting microvascular invasion of combined hepatocellular-cholangiocarcinoma (≤5 cm) |
| Received:March 23, 2021 Revised:June 30, 2021 Click here to download the full text |
| Citation of this paper:LU Xiu-liang,NI Xiao-yan,ZHOU Lin-xi,ZHOU Chang-wu,YANG Chun,ZENG Meng-su.Application value of apparent diffusion coefficient in predicting microvascular invasion of combined hepatocellular-cholangiocarcinoma (≤5 cm)[J].Chinese Journal of Clinical Medicine,2021,28(5):789-794 |
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| Author Name | Affiliation | E-mail | | LU Xiu-liang | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | NI Xiao-yan | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | nixiaoyan1103@126.com | | ZHOU Lin-xi | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | ZHOU Chang-wu | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | YANG Chun | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | ZENG Meng-su | Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | |
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| Abstract:Objective: To explore the predictive value of apparent diffusion coefficient (ADC) in predicting microvascular invasion (MVI) in combined hepatocellular-cholangiocarcinoma (cHCC-CCA). Methods: From January 2016 to June 2019, 67 patients with mixed liver cancer (≤ 5 cm) confirmed by preoperative MRI and postoperative pathology from Zhongshan Hospital, Fudan University were included and divided into MVI positive group (n=26) and MVI negative group (n=41) according to the presence or absence of MVI. Univariate and multivariate analyses were used to analyze the risk factors of MVI, and the receiver operating characteristic curve was used to evaluate their diagnostic efficacy. Results: The univariate retrospective analysis showed that the ADC value of the microvascular invasion positive group and the negative group was (1.268±0.571)×10-3 mm2/s and (1.432±0.315)×10-3 mm2/s, with statistically significant difference between the two groups (P=0.009). There was also a statistically significant difference in the peritumoral enhancement between the microvessel-positive group and the negative group (P=0.001). Logistic regression results showed that, ADC value is an independent predictor of microvascular invasion in cHCC-CCA (HR=5.421, P=0.025). The ADC value predicted the AUC of cHCC-CCA microvascular invasion was 0.685 (95%CI 0.539-0.756). When the ADC cut-off value is 1.378×10-3 mm2/s, the Youden index is 0.4. Conclusions: ADC value is an independent factor predicting microvascular invasion of combined hepatocellular-cholangiocarcinoma (≤ 5 cm), and has a certain predictive value for MVI. |
| keywords:combined hepatocellular-cholangiocarcinoma apparent diffusion coefficient microvascular invasion |
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