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Changes of serum N-MID and β-CTX levels and their relationships with bone metabolism in patients with type 2 diabetes mellitus
Received:March 16, 2021  Revised:May 28, 2021  Click here to download the full text
Citation of this paper:WANG Wei,MA Li-li,ZHANG Qiong.Changes of serum N-MID and β-CTX levels and their relationships with bone metabolism in patients with type 2 diabetes mellitus[J].Chinese Journal of Clinical Medicine,2021,28(4):588-593
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Author NameAffiliation
WANG Wei Department of Clinical Laboratory, Fuyang People's Hospital, Fuyang 236004, Anhui, China 
MA Li-li Department of Clinical Laboratory, Fuyang People's Hospital, Fuyang 236004, Anhui, China 
ZHANG Qiong Department of Clinical Laboratory, Fuyang People's Hospital, Fuyang 236004, Anhui, China 
Abstract:Objective: To analyze the relationship between serum N-MID osteocalcin (N-MID), β-cross-linked C-telopeptide of type Ⅰ collagen (β-CTX) levels and bone metabolism in patients with type 2 diabetes mellitus. Methods: A total of 235 patients with type 2 diabetes mellitus diagnozed and treated from February 2017 to February 2020 were included.The patients were divided into normal bone mass group (n=94), osteopenia group (n=92) and osteoporosis group (n=49) according to bone mineral density (BMD). Serum levels of N-MID, β-CTX, parathyroid hormone (PTH), and 25(OH)D3 were measured and compared among the three groups. The correlation between serum N-MID, β-CTX and BMD, PTH, and 25(OH)D3 were analyzed. Receiver-operating characteristic curve was employed to assess the capability of biochemical parameters to distinguish osteoporosis.Results: The age and course of diabetes mellitus were increased in normal bone mass, osteopenia group, and osteoporosis groups in sequence (P<0.01). The levels of serum N-MID, β-CTX, and PTH in osteoporosis group were significantly higher than those in normal bone mass group and osteopenia group (P<0.05). Pearson analysis showed that serum N-MID and β-CTX levels were negatively correlated with BMD (P<0.05) and positively correlated with PTH (P<0.05). Howere there was no relationship between N-MID, β-CTX and 25(OH)D3. The serum N-MID was positively correlated with β-CTX (P<0.01). The area under the curve for N-MID and β-CTX to distinguish osteoporosis from normal bone mass were 0.86 and 0.85, and the specificity were 100.00% and 96.81%, respectively(P<0.001).Conclusions: The determination of serum levels of N-MID and β-CTX is helpful to understand the changes of bone metabolism of type 2 diabetes mellitus with osteoporosis, so that to provide evidence for the evaluation of condition.
keywords:N-MID osteocalcin  β-cross-linked C-telopeptide of type Ⅰ collagen  type 2 diabetes mellitus  osteoporosis  bone metabolism
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