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Controllability comparison between progestin-primed ovarian stimulation and mild stimulation protocols in patients with diminished ovarian reserve in oocytes retrieval cycle
Received:March 01, 2021  Revised:May 25, 2021  Click here to download the full text
Citation of this paper:FAN Xing-yan,YÜ Sha,WANG Yun,KUANG Yan-ping.Controllability comparison between progestin-primed ovarian stimulation and mild stimulation protocols in patients with diminished ovarian reserve in oocytes retrieval cycle[J].Chinese Journal of Clinical Medicine,2021,28(4):539-543
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Author NameAffiliationE-mail
FAN Xing-yan Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China  
YÜ Sha Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China  
WANG Yun Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China  
KUANG Yan-ping Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China kuangyanp@126.com 
Abstract:Objective: To compare the clinical outcomes of progestin-primed ovarian stimulation (PPOS) with mild stimulation protocol in patients with diminished ovarian reserve.Methods: The patients with diminished ovarian reserve received in vitro fertilization-embryo transfer were retrospectively analyzed and divided into two groups:PPOS group and clomiphene citrate mild stimulation group. Then, the rate of premature luteinizing hormone surge, dose and duration of gonadotropin, retrieved oocyte number (rate), mature oocyte number (rate), fertilization oocytes number (rate), the number of viable embryos, etc, were analyzed. Results: There were 972 patients included, with 486 patients in each group. The premature luteinizing hormone surge rate in PPOS protocol was significantly lower than that in the mild stimulation group (6.17% vs 39.92%, P<0.001). There were no significant differences in retrieved oocytes number (rate), mature oocyte number, and some embryological characteristics between the two groups. The duration and dose of gonadotropin in the PPOS group were significantly greater than those in the mild stimulation group (P<0.001). Conclusions: Compared with mild stimulation protocol, the PPOS protocol can effectively inhibit the premature luteinizing hormone surge in diminished ovarian reserve patients. Therefore, PPOS protocol can offer an option for diminished ovarian reserve patients who received in vitro fertilization-embryo transfer.
keywords:diminished ovarian reserve  progestin-primed ovarian stimulation  clomiphene citrate mild stimulation  premature luteinizing hormone surge
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