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Effect of metoprolol combined with ivabradine on patients with stable angina pectoris
Received:February 04, 2021  Revised:July 06, 2021  Click here to download the full text
Citation of this paper:LU Wei-wei,LIU Bo.Effect of metoprolol combined with ivabradine on patients with stable angina pectoris[J].Chinese Journal of Clinical Medicine,2021,28(4):661-664
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Author NameAffiliationE-mail
LU Wei-wei Department of General Practice, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China  
LIU Bo Department of Cardiology Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China liubo@xinhuamed.com.cn 
Abstract:Objective: To explore the effect of metoprolol combined with ivabradine on patients with stable angina pectoris.Methods: From January 2019 to January 2020, 126 patients with stable angina pectoris were selected from Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, and were randomly divided into the control group (n=63) and experimental group (n=63). The prospective observation and single-center trial were conducted. The patients in the control group was treated with metoprolol(once a day, the initial dose was 23.75 mg, and the dosage was increased to 47.5 mg within 2 weeks), and patients in the experimental group was treated with ivabradine based on the treatment of the control group(the initial dose was 5 mg and twice daily). After 8 weeks of treatment, the heart rate, angina symptoms, and prognosis of patients between the two groups were compared.Results: Before treatment, there was no statistically significant difference in the base data between the two groups. After treatment, the heart rates in the experimental group and the control group were (59.13±9.26) times/min and (67.13±8.43) times/min, respectively, which were significantly lower than before treatment (P<0.05), and the effect in the experimental group was better (P<0.05). At the same time, the curative effect on angina pectoris in the experimental group was significantly better than that in the control group, and the difference in the total effective rate was statistically significant (87.3% vs 76.2%; χ2=4.79, P=0.039). In short-term prognosis monitoring, the incidences of malignant arrhythmia and recurrent myocardial infarction decreased significantly in the experimental group than those in the control group (P<0.05).Conclusions: Metoprolol combined with ivabradine can significantly improve angina symptoms, and is helpful to further improve the prognosis.
keywords:metoprolol  ivabradine  stable anginapectoris  heart rate
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