| Advances in autophagy regulation of macrophages involved in the construction of tumor microenvironment |
| Received:December 22, 2020 Revised:February 07, 2021 Click here to download the full text |
| Citation of this paper:GAO Zheng,CHEN Jia-feng,FU Xiu-tao,DING Zhen-bin.Advances in autophagy regulation of macrophages involved in the construction of tumor microenvironment[J].Chinese Journal of Clinical Medicine,2021,28(5):894-899 |
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| Author Name | Affiliation | E-mail | | GAO Zheng | Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | CHEN Jia-feng | Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | FU Xiu-tao | Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | DING Zhen-bin | Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | ding.zhenbin@zs-hospital.sh.cn |
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| Abstract:Autophagy is involved in maintaining cell homeostasis as a highly conserved degradation pathway of intracellular metabolite and senescent or damaged organelles. Tumor-associated macrophages (TAMs) are the key cells in the tumor microenvironment, which can promote tumorogenesis, development, and metastasis through M2 polarization. Autophagy is an important component in the construction of the tumor microenvironment by regulating TAMs polarization and metabolism. This article reviews the mechanism of autophagy regulating the interaction between macrophages and tumor microenvironment, aiming to provide new potential theoretical autophagy regulatory targets for anti-tumor therapy. |
| keywords:autophagy tumor-associated macrophages tumor microenvironment |
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