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Predictive value of serum sodium combined with hematocrit for short-term prognosis of acute heart failure
Received:December 17, 2020  Revised:April 06, 2021  Click here to download the full text
Citation of this paper:WANG Yu,ZHANG Ying-jie.Predictive value of serum sodium combined with hematocrit for short-term prognosis of acute heart failure[J].Chinese Journal of Clinical Medicine,2021,28(5):874-878
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Author NameAffiliationE-mail
WANG Yu Graduate Student Training Base, Fuxin Central Hospital, Jinzhou Medical University, Fuxin 123000, Liaoning, China  
ZHANG Ying-jie Department of Cardiovascular Medicine, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, Liaoning, China zhangyingjiejinzhou@126.com 
Abstract:Objective: To explore the relationship between hyponatremia combined with hematocrit and the short-term prognosis of patients with acute heart failure. Methods: 498 patients with acute heart failure admitted to Fuxin Central Hospital of Jinzhou Medical University from January 2019 to July 2020 were selected. The clinical conditions, basic diseases, echocardiographic results, and laboratory indicators within 24 hours of admission were recorded. According to serum sodium, patients with acute heart failure were divided into normonatremic group (serum sodium ≥ 135 mmol/L) and hyponatremic group (serum sodium<135 mmol/L). The patients with hyponatremia were divided into the dilutional hyponatremic group (hematocrit <40% for male or < 37% for female) and depletional hyponatremic group (hematocrit ≥ 40% for male or hematocrit ≥ 37% for female) based on hematocrit levels. The mortality rate during hospitalization, death, and readmission within 30 and 90 days after discharge were compared in each group. The predictive value of Serum sodium combined with hematocrit on the short-term prognosis of patients after discharge was analyzed. Results: 498 patients with acute heart failure were included, 86 patients of the included patients had hyponatremia, included 34 patients with dilutional hyponatremia and 52 patients with depletional hyponatremia. Adverse events at the period of observation occurred in 167 patients, including 23 patients in the dilutional hyponatremia group, 22 patients in the depletional hyponatremia group, and 122 patients in the normonatremic group. After adjustment for baseline characteristics, dilutional hyponatremia was independent risk factor with the incidence of adverse events for acute heart failure within 30 days and 90 days after discharge (P<0.05). The area under the curve (AUC) of serum sodium, HCT, and their combination in predicting short-term prognosis of patients with acute heart failure were 0.734, 0.657, and 0.762 (P<0.001). Conclusions: Dilutional hyponatremia is an independent predictor of short-term prognosis in patients with acute heart failure, with high predictive value.
keywords:heart failure  hyponatremia  hematocrit
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