| Preliminary study on the efficacy of alteplase intravenous thrombolysis combined with dual antiplatelet in patients with stroke warning syndrome |
| Received:November 30, 2020 Revised:February 22, 2021 Click here to download the full text |
| Citation of this paper:WANG Ning-ning,FENG Guo-dong,WU Xü-qing,SONG Fei-fei,BAO Hai-feng,MA Yu,FAN Wei.Preliminary study on the efficacy of alteplase intravenous thrombolysis combined with dual antiplatelet in patients with stroke warning syndrome[J].Chinese Journal of Clinical Medicine,2021,28(4):665-669 |
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| Author Name | Affiliation | E-mail | | WANG Ning-ning | Department of Neurology, Qingpu Branch, Zhongshan Hospital, Fudan University, Shanghai 201700, China | | | FENG Guo-dong | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | WU Xü-qing | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | SONG Fei-fei | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | BAO Hai-feng | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | MA Yu | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | FAN Wei | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | fan.wei@zs-hospital.sh.cn |
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| Abstract:Objective: To explore the safety and efficacy of alteplase intravenous thrombolysis combined with dual antiplatelet therapy in patients with stroke warning syndrome. Methods: From January 2017 to May 2019, 8 patients with stroke early warning syndrome were treated with alteplase intravenous thrombolysis in Zhongshan Hospital, Fudan University and followed up for 6 months. The efficacy of intravenous thrombolysis combined with dual antiplatelet therapy and prognosis of the patients were discussed in conjunction with the literature. Results: Seven patients had cerebrovascular disease risk factors. The frequency of attacks decreased within 24 hours of intravenous thrombolysis, but 6 patients had neurological deficits. By giving dual antiplatelet therapy combined with individualized blood pressure management, the patient's condition was stabilized, and their neurological deficits improved 2 weeks after onset. All patients had a good prognosis 6 months after onset. Conclusions: The alteplase intravenous thrombolysis combined with dual antiplatelet therapy and personalized blood pressure management are beneficial for stabilizing the condition and improving the prognosis of patients with stroke warning syndrome. |
| keywords:stroke warning syndrome alteplase intravenous thrombolysis dual antiplatelet therapy |
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