Objective To explore the predictive value of the monocyte to high-density lipoprotein cholesterol ratio (MHR) on the prognosis of patients with acute ischemic stroke (AIS) for three months.
Methods A total of 313 AIS patients hospitalized in the Department of Neurology, The Second Affiliated Hospital of Navy Medical University from July 2019 to September 2020 were retrospectively included. According to the modified Rankin Scale (mRS), 313 patients were divided into good prognosis group (mRS ≤ 2, n=260) and poor prognosis group (mRS >2, n=53). Multivariate logistic regression analysis was performed to evaluate the relationship between MHR and poor prognosis. The prognostic value of MHR in AIS patients was evaluated by ROC curve method.
Results Compared with the good prognosis group, the poor prognosis group had higher MHR. Multivariate logistic regression analysis showed that higher MHR (OR=2.690, 95%CI 1.017-7.111, P=0.046) was independently associated with poor functional outcomes after 3 months. ROC curve analysis showed that the area under the curve (AUC) for MHR was 0.851 (95%CI 0.788-0.913, P < 0.001) and the best predictive cutoff value was 4.580, with a sensitivity of 81.1% and a specificity of 79.2%.
Conclusions MHR is an effective and independent predictor of poor outcomes in patients with AIS.
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