摘要: |
目的: 分析定量CT(QCT)与MRI非对称回波的最小二乘估算法迭代水脂分离序列(IDEAL-IQ)在2型糖尿病患者胰腺脂肪含量测定中的相关性及一致性。方法: 纳入67例2型糖尿病志愿者,男性33例、女性34例,平均年龄(66.55±6.23)岁。用MRI IDEAL-IQ技术及QCT对患者的胰腺头、体及尾部区域的脂肪含量进行定量测量,获得患者的MRI胰腺脂肪分数(MR-PFF)及CT胰腺脂肪分数(CT-PFF)。对MR-PFF与CT-PFF进行相关性分析,并进行Bland-Altman一致性分析。同时分析MR-PFF与肝脏脂肪含量、腹围、体质量指数(BMI)等的相关性。结果: 67例受试者平均腹围(83.34±10.1)cm、平均BMI(24.02±2.96)kg/m2,平均肝脏脂肪含量(5.28±2.76)%。腹围及肝脏脂肪含量与MR-PFF相关(P<0.05)。MR-PFF和CT-PFF分别为(12.21±10.71)%、(19.9±10.61)%,两者呈显著线性相关(r=0.842, P<0.001),MR-PFF=-4.169+0.818×CT-PFF;Bland-Altman分析示两者一致性较好(95%CI -4.15%~19.75%,P=0.044),3例样本在该区间外。结论: QCT与MRI测量的胰腺脂肪含量有明显的相关性和很好的一致性,可用于胰腺脂肪含量的定量测量。 |
关键词: 脂肪胰 2型糖尿病 磁共振 定量CT 胰腺脂肪分数 |
DOI:10.12025/j.issn.1008-6358.2021.20210979 |
分类号:R576 |
基金项目:江苏省自然科学基金面上项目(BK20201494). |
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Application of quantitative CT in the pancreatic fat deposition in patients with type 2 diabetes |
ZHU Hong1,2, ZHANG Zong-jun2, WU Fei-yun1
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1.Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China;2.Department of Radiology, the Integrated Traditional Chinese and Western Medicine Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China
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Abstract: |
Objective: To analyze the correlation and consistency of MRI IDEAL-IQ and quantitative CT (QCT) in the quantitation of pancreatic fat content in patients with type 2 diabetes.Methods: Sixty-seven volunteers with type 2 diabetes (33 men and 34 women, mean age years) underwent both MRI IDEAL-IQ and QCT examinations. The regions of interest (ROI) were placed at the head, body, and tail of the pancreas to obtain MRI pancreas fat fraction (MR-PFF) and CT-PFF. The correlation between MR-PFF and CT-PFF was analyzed, and the consistency of them was analyzed by Bland-Altman. The correlations between MR-PFF and liver fat content, abdominal circumference, and body mass index (BMI) were also analyzed.Results: In sixty-seven volunteers, the mean abdominal circumference was (83.34±10.1) cm, BMI was (24.02±2.96) kg/m2, and liver fat content was (5.28±2.76)%. The abdominal circumference and liver fat content were correlated with MR-PFF (P<0.05). MR-PFF and CT-PFF were (12.21±10.71)% and (19.9±10.61)%, respectively. CT-PFF showed a significant linear correlation with MR-PFF (r=0.842, P<0.001). MR-PFF=-4.169+0.818×CT-PFF. The Bland-Altman analysis results showed that the 95% CI of consistency was -4.15%-19.75% (P=0.044), and there were 3 values outside of the interval.Conclusions: The pancreatic fat contents measured by QCT and MRI have good correlation and consistency, and QCT can be used to measure pancreatic fat content. |
Key words: fatty pancreas type 2 diabetes magnetic resonance quantitative CT pancreas fat fraction |