摘要: |
目的: 探索肠癌肝转移灶超声造影增强方式的肿瘤相关影响因素。方法: 收集2015年3月至2018年3月就诊于复旦大学附属中山医院,未经治疗的同时性肠癌肝转移且原发灶及转移灶可直接同期根治性切除的76例病例资料。行术前肝脏超声造影检查后,根据转移灶的增强方式分为3组:环状增强组16例,整体不均匀增强组29例,整体均匀增强组31例。比较3组病例的临床病理特征,利用统计学方法分析转移灶增强方式的肿瘤相关影响因素。结果: 肠癌肝转移灶增强方式的影响因素分别是造影病灶最大径、肝转移灶体积之和、癌结节状态、术前血清癌抗原19-9(CA19-9)水平及癌胚抗原(carcino-embryonic antigen,CEA)水平,独立影响因素分别是造影病灶最大径、肝转移灶体积之和及术前CA19-9水平。结论: 超声造影增强方式具有肿瘤临床病理特征基础,对判断肿瘤情况有一定价值,能否反映肝脏的肿瘤负荷,判断肿瘤标志物水平,与癌结节的关系,能否有助于临床做预后判断值得进一步探究。 |
关键词: 超声造影 肝转移 结直肠癌 同期切除 增强方式 |
DOI:10.12025/j.issn.1008-6358.2020.20192157 |
分类号:R445.1 |
基金项目:国家自然科学基金(81571676). |
|
Analysis of tumour-associated influencing factors for enhancement pattern of colorectal liver metastases in contrast-enhanced ultrasonography |
ZHANG Xiao-long, LU Qing, WANG Xi, YUAN Hai-xia, TANG Yang, CHEN Kai-ling, WANG Wen-ping
|
Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China
|
Abstract: |
Objective: To investigate tumour-associated influencing factors for enhancement pattern of colorectal liver metastases (CLM) in contrast-enhanced ultrasonography (CEUS). Methods: Previously untreated patients with CLM were continuously recruited from applicants of our institute. Liver CEUS was performed in patients with surgically resectable primary and secondary cancer. 76 patients were finally incorporated into the analysis. After preoperative contrast-enhanced ultrasonography of liver, according to enhancement patterns, it was divided into three groups:ring enhancement group (16 cases), global inhomogeneous enhancement group (29 cases) and global homogeneous enhancement group (31 cases). Tumour-associated cliniocpathological characteristics was compared between three groups. Then influencing factors of enhancement pattern and the interrelationship were further analyzed. Results: Influencing factors of enhancement pattern were size of index lesion, sum of volume of liver metastases, tumour deposits status, preoperative CA19-9 level and carcino-embryonic antigen (CEA) level. The independent influencing factors of enhancement pattern were size of index lesion, sum of volume of liver metastases and preoperative CA19-9 level. Conclusions: Enhancement pattern of CLM in CEUS does have tumour-associated clinicopathological bases, It has certain value for judging tumor condition, whether contrast-enhanced ultrasound can reflect the tumor load of the liver, judge the level of tumor markers, the relationship between contrast-enhanced ultrasound and tumor nodule and whether it can be helpful for clinical prognosis judgment should be further explored. |
Key words: contrast-enhanced ultrasonography liver metastases colorectal carcinoma simultaneous resection enhancement pattern |