摘要: |
目的:比较不同体质指数(body mass index, BMI)早发2型糖尿病(T2DM)的临床特征。方法:选择临床初次诊断为T2DM的年龄≤35岁的患者287例,按BMI不同分为超重组(BMI≥24 kg/m2)190例和非超重组(BMI<24 kg/m2)97例,比较两组患者在一般资料和生化指标方面的差异。结果:超重组患者以男性为主,高血压、非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)的发生率均明显高于非超重组(P<0.01)。超重组患者的空腹血糖(FPG)、空腹胰岛素(FINS)、餐后2 h胰岛素(2 h INS)、空腹C肽(FC-P)、餐后2 h C肽(2 h C-P)、胰岛素抵抗指数(HOMA-IR)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酸转肽酶(γ-GT)、总胆固醇(TC)、三酰甘油(TG)、血肌酐(SCr)、血尿酸(UA)水平均高于非超重组(P<0.01);超重组患者的糖化血红蛋白(HbA1c)、糖化白蛋白(GA)、高密度脂蛋白胆固醇(HDL-C)水平较非超重组低(P<0.05)。结论:超重的早发T2DM患者发生高血压、NAFLD的比例高,肝肾功能减退、胰岛素抵抗和代谢功能紊乱较严重。 |
关键词: 早发型 2型糖尿病 体质指数 临床特点 |
DOI: |
分类号:R 587.1 |
基金项目:国家自然科学基金面上项目(81272665). |
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Clinical characteristics of early-onset type 2 diabetes mellitus patients with different body mass index level |
CAO Jing-zhu1△, WANG Yuan-chen2△, HONG Hui-lan3, HUANG Qin1*
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1. Department of Endocrinology, Changhai Hospital, Navy Military Medical University, Shanghai 200433, China
2. School of Basic Medicine, Navy Military Medical University, Shanghai 200433, China
3. Department of Special Needs Clinic, Changhai Hospital, Navy Military Medical University, Shanghai 200433, China
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Abstract: |
Objective:To compare the clinical characteristics of early-onset type 2 diabetes mellitus (T2DM) patients with different body mass index (BMI). Methods:Totally 287 cases of initial-diagnosed T2DM patients (age≤35 years old) were divided into overweight group (BMI≥24 kg/m2, n=190) and normal-weight group (BMI<24 kg/m2, n=97). The general information and biochemical indexes were compared between the two groups. Results:Compared with the normal-weight group, the overweight group had significantly higher proportion of male patients, significantly higher prevalence of hypertension and non-alcoholic fatty liver disease (NAFLD, P<0.01). Compared with normal-weight group, the patients in overweight group had significantly higher levels of fasting glucose (FPG), fasting serum insulin (FINS), postprandial 2-hour insulin (2 h INS), fasting C-peptide (FC-P), postprandial 2-hour C-peptide (2 h C-P), insulin resistance index (HOMA-IR), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (γ-GT), total cholesterol (TC), triglyceride (TG), serum creatinine (SCr), and uric acid (UA, P<0.01). While the levels of glycated hemoglobin (HbA1c), glycated albumin (GA), high density lipoprotein cholesterol (HDL-C) were significantly lower than those in the normal-weight group (P<0.05). Conclusions:Early-onset and overweight T2DM patients have a higher prevalence of hypertension and NAFLD, with more serious liver and renal dysfunction, HOMA-IR, and metabolism disorders. |
Key words: early-onset type 2 diabetes mellitus body mass index clinical characteristics |