摘要: |
糖尿病心肌病(diabetic cardiomyopathy, DCM)是一种基于糖尿病,排除心脏本身疾病导致的独立的缺血性心肌疾病。DCM的发病机制由多因素造成,目前并不十分明确,其主要由心肌细胞的损伤、血糖浓度增高、能量代谢紊乱及微血管病变引起。脂联素(adiponectin, APN)具有降血糖、调血脂、抗凋亡、抗炎症反应、抗氧化作用,也能预防动脉粥样硬化,与DCM的发生发展具有密切关系。本文就APN在DCM中作用的研究进展作一综述。 |
关键词: 脂联素 糖尿病心肌病 氧化应激 细胞凋亡 纤维化 |
DOI: |
分类号:R 542.2 |
基金项目:国家自然科学基金面上项目(00019509),江西省科技厅-领军人才培养计划(赣鄱英才555工程)(700207004). |
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Research progress on prevention and treatment of adiponectin in diabetic cardiomyopathy |
WU Xia1△, WU Xue-ting2△, HUANG Lei-tao3, ZHOU Xue-liang1, TAO En-de4, LIU Ji-chun1*
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1.Department of Thoracic and Cardiovascular Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China
2.Family Planning Service Station, Xiangcheng 466200, Henan, China
3.Department of Orthopedics, the Fourth Affiliated Hospital of Nanjing Medical University, Nanjing 210031, Jiangsu, China
4.Department of Cardiac Surgery, Wuhan Asia Heart Hospital, Wuhan 430022, Hubei, China
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Abstract: |
Diabetic cardiomyopathy (DCM) is an independent ischemic heart disease that occurs on the basis of diabetes, excluding diseases originated from the heart itself. The pathogenesis of DCM is caused by multiple factors and is still not well elucidated. It involves the injury of cardiac myocytes, hyperglycemia, energy metabolism disorder, and cardiac microvascular disease. Adiponectin (APN) has been found to be able to reduce the level of glycemia and regulate blood lipids, and has anti-apoptotic, anti-inflammatory, and antioxidant properties, as also be able to prevent atherosclerosis, and has close relationship with the development of DCM. Therefore, this article describes and summarizes the role of adiponectin in DCM. |
Key words: adiponectin diabetic cardiomyopathy oxidative stress apoptosis fibrosis |