摘要: |
越来越多的长链非编码RNA(long non-coding RNA, lncRNA)被发现在肿瘤中发挥极其重要的作用。前列腺癌相关转录因子1(prostate cancer associated transcript-1, PCAT-1)作为一种lncRNA,在许多人类肿瘤组织中过表达,并与肿瘤细胞的增殖、凋亡、侵袭转移及患者的预后密切相关,其机制却不十分清晰与完善。本文就PCAT-1作为新的分子标志物或潜在靶点,在肿瘤的诊断、治疗及患者预后评估等方面一一阐述。 |
关键词: 长链非编码RNA 前列腺癌相关转录因子1 肿瘤 肿瘤标志物 |
DOI: |
分类号:R 737.25 |
基金项目:国家自然科学基金(81602088),中国博士后科学基金(2017M621305),黑龙江省博士后科学基金(LBH-Z16096),黑龙江省卫生计生委科研课题(2016-049). |
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Research progress of prostate cancer associated transcript-1 in malignant tumors |
ZHOU Yuan-shi, LI Xiang, JIANG Xing-ming*, CUI Yun-fu*
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Department of Hepatopancreatobiliary Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China
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Abstract: |
Long non-coding RNA (lncRNA) play important roles in cancer progression. Studies have shown that as a lncRNA, prostate cancer associated transcript-1 (PCAT-1) is aberrant overexpressed in varieties of cancers, which is closely correlated to the proliferation, apoptosis, invasion, metastasis of tumor cells and the prognosis of tumor patients, however, the mechanism is not well elucidated. In this review, PCAT-1 as a new molecular marker or potential target is described in terms of tumor diagnosis, treatment and prognosis. |
Key words: long non-coding RNA prostate cancer associated transcript-1 tumor tumor biomarker |