摘要: |
目的:探讨TRIM44和基质金属蛋白酶9(MMP9)蛋白在肝内胆管癌(ICC)中的表达及临床意义。方法:采用免疫组织化学法检测87例ICC患者肿瘤组织TRIM44、MMP9蛋白的表达,进一步分析两者表达与患者临床病理指标及预后的相关性;采用Spearman相关性分析探讨TRIM44和MMP9表达的相关性;采用Kaplan-Meier法和Cox风险回归模型分析TRIM44、MMP9表达对患者预后的影响。结果:ICC肿瘤组织TRIM44、MMP9蛋白呈过表达状态,且TRIM44与MMP9表达正相关(P<0.001)。TRIM44与淋巴结转移显著相关(P=0.014);MMP9与肿瘤大小、AFP水平与淋巴结转移显著正相关(P<0.05),两者同时过表达提示患者预后不良。结论:ICC组织TRIM44和MMP9呈过表达,且二者密切相关;两者同时高表达提示ICC患者预后不良。 |
关键词: TRIM44 基质金属蛋白酶9 肝内胆管癌 预后 |
DOI:10.12025/j.issn.1008-6358.2018.20180698 |
分类号:R 735.7 |
基金项目:江苏省“六大人才高峰”项目(2014-WSW-076). |
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Expression and clinical significance of TRIM44 and MMP9 in intrahepatic cholangiocarcinoma |
PENG Rui1,HUANG Xiao-yong2,CAI Jia-bin2,KE Ai-wu2,SHI Guo-ming2,BAI Dou-sheng1,3*
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1.The Second Xiangya Hospital, Central South University, Changsha 410000, Hunan, China2.Institute of Liver Cancer, ZhongshanHospital, Fudan University, Shanghai 20032, China3.The Subei People’s Hospital, Yangzhou University, Yangzhou 225001, Jiangsu, China
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Abstract: |
Objective:To investigate the expression and clinical significance of TRIM44 and MMP9 in intrahepatic cholangiocarcinoma (ICC). Methods:The expression of TRIM44 and MMP9 in 87 ICC patients were analyzed by immunohistochemistry. And the clinical significance of TRIM44 and MMP9 were investigated by Kaplan-Meier and Cox regression models. Results:The expressions of TRIM44 and MMP9 were upregulated in tumor tissues of ICC. TRIM44 was positively associated with MMP9 expression in ICC (P<0.001). TRIM44 expression was significantly correlated with the lymph node metastasis (P=0.014), and MMP9 was significantly correlated with the tumor size, AFP concentration, and lymph node metastasis (P<0.05). Simultaneous overexpression of TRIM44 and MMP9 suggested poor prognosis of ICC patients. Conclusions:TRIM44 and MMP9 are overexpressed in ICC and are closely related to each other. The high expressiones of both suggest poor prognosis of ICC patients. |
Key words: TRIM44 MMP9 ICC prognosis |