摘要: |
随着分子遗传学的发展,人们对家族性胃癌的遗传学基础、发病机制、临床病理特征有了新的认识。积极开展家族性胃癌的遗传学检测,对家族性胃癌家系中CDH1胚系突变者采取合理的预防性干预治疗,能有效地改善家族性胃癌患者预后。本文就近年来国内外关于家族性胃癌的研究进展作一综述。 |
关键词: 家族性胃癌 CDH1基因 胚系突变 全胃切除 |
DOI:10.12025/j.issn.1008-6358.2018.20180095 |
分类号:R 730.1 |
基金项目:复旦大学附属中山医院科研发展基金(2016ZSFZ60). |
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Research progress on the familial gastric cancer |
ZHOU Rong-jian,QIN Jing*
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Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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Abstract: |
With the development of the molecular genetics, we have got a better understanding about the fundamentals of genetics, pathogenesis, and clinicopathological characteristics of the familial gastric cancer. Genetic tests should be carried out in familial gastric cancer patients and reasonable preventive intervention could effectively improve the prognosis of patients with familial gastric cancer who have CDH1 germline mutations. This article reviews the research progress on familial gastric cancer at home and abroad in recent years. |
Key words: familial gastric cancer CDH1 gene germline mutation total gastrectomy |