摘要: |
目的:探讨乳腺浸润性微乳头状癌(invasive micropapillary carcinoma, IMPC)的临床特征。方法:回顾性分析1993年6月至2017年7月中国3个乳腺中心205例IMPC患者的临床病理资料,与同期临床病理资料完整的410例非IMPC浸润性导管癌(invasive ductal carcinoma, IDC)患者进行比较,总结IMPC的临床病理特点。结果:两组患者年龄分布、肿瘤大小、淋巴结转移率、组织学分级、孕激素受体(progesterone receptor, PR)、人类表皮生长因子受体2(human epidermal growth factor receptor 2, HER2)表达、Ki-67值、分子分型差异有统计学意义(P<0.05)。两组患者雌激素受体(estrogen receptor, ER)表达差异无统计学意义。结论:中国IDC患者中,IMPC发病率较低,患者较年轻,肿瘤较大、淋巴结转移率较高、组织学分级较高,孕激素受体、HER2阴性率高。IMPC中,Luminal B型乳腺癌比例较高,三阴型乳腺癌比例较低。 |
关键词: 乳腺癌 浸润性微乳头状癌 淋巴结转移 |
DOI:10.12025/j.issn.1008-6358.2018.20171133 |
分类号:R 736.3 |
基金项目:国家自然科学基金(81702586, 81502267),复旦大学附属中山医院青年基金( 2016ZSQN59). |
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Clinical features of patients with invasive micropapillary carcinoma of breast among multiple centers in China |
NI Xiao-jian1,KUANG Xia-ying2,ZHOU Ping3,ZHANG Hong-wei1,ZHU Wei1*
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1.Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China2.Department of Breast Surgery, the First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, Guangdong, China3.Department of Breast Surgery, the Third Hospital of Nanchang, Nanchang 330009, Jiangxi, China
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Abstract: |
Objective:To investigate the clinicopathologic features of invasive micropapillary carcinoma (IMPC) of breast. Methods:The clinical and pathologic features of 205 cases of breast IMPC during June 1993 to July 2017 were retrospectively analyzed. A total of 410 patients with invasive ductal carcinoma excluding IMPC in the same period were selected as control. Results:There were statistically significances in the age distribution, tumor size, lymph node metastasis rate, histological grading, progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) expression, value of Ki-67, molecular classification between IMPC and IDC patients (P<0.05). However, estrogen receptor (ER) status was not statistically significant. Conclusions:IMPC is a rare type of breast cancer with aggressive growth. Patients with IMPC were usually younger, with larger tumors, but higher lymph node metastasis rate, histological grade, hormone receptor positive and HER2 negative rates. There was a higher proportion of Luminal B breast cancer in IMPC, and lower in triple negative breast cancer. |
Key words: breast cancer invasive micropapillary carcinoma lymph node metastasis |